2,4-Dichloroquinazoline → HCID 86600305, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,4-dichloro-quinazoline (0.25 g, 1.26 mmol) in isoprapanol (6 mL) were added t-butyl-(1S,4S)-(−)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (0.25 g, 1.26 mmol) and the solution was heated at 60° C. for 4 h. The reaction was concentrated in vacuo and the residue was chromatographed over silica with 25:10:65, 35:10:55, and 50:10:40 EtOAc-CH2Cl2-Hexane; 1%, 3%, and 5% MeOH/CH2Cl2 to give the title compound. MS (ES+): 361.1 [M+H]+.

Provenance & Evidence