Acetone → HCID 68905886, compound

Participants

Reaction Steps

A mixture of 75 mg (0.2 mmol) {4-[2-(2,5-diaza-bicyclo[2.2.1]hept-2-yl)-thiazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine in 5 mL chloroform was treated with 0.15 mL (2mmol) acetone, 120 mg (2 mmol) NaBH3(CN) and 1 mL methanol consequently. The mixture was stirred at rt for 15 h. MS showed all starting materials were converted. The mixture was diluted with 100 mL DCM, washed with 20 mL sat. NaHCO3, dried over anhydrous Na2SO4. After purification by chromatography, obtained the title compound as a yellow solid. MS (ES+): 420 (M+H)+.

Provenance & Evidence