Chloroform → HCID 68908188, compound

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Reaction Steps

The title compound was analogously synthesized by the method described in Example 55 with the addition of one step. To a solution of benzyl-(4-[5-(2,5-diaza-bicyclo[2.2.1]hept-2-yl)imidazo[1,2-c]pyrimidin-7-yl]pyridin-2-yl)amine (0.400 g) was added chloroform (4 mL) followed by acetone (5 mL), and sodium triacetoxy borohydride (0.600 mg) at 70° C. After 30 min, work up between dichloromethane and sodium bicarbonate followed by flash column purification afforded the title compound as an off white solid. MS (ES+): 440 (M+H)+; (ES−): 438(M−H)−.

Provenance & Evidence