反应详情

Add H2SO4 (4.5 g) to a suspension of 3-Hydroxy-2-hydroxymethyl-2-methyl-propionic acid (100 g) in MeOH (1 L, HPLC grade solvent) and stir at room temperature. for about 70 hours. Remove the solvent and partition the residue between EtOAc (1 L) and H2O (100 mL). Re-extract the aqueous layer with EtOAc, and dry the combined organic fractions over MgSO4. Filter and concentrate under reduced pressure. Crude mixture can be used without further purification. 1H NMR (CDCl3, 300 MHz): δ ppm 3.9 (d, 2H, J=11.1 Hz), 3.76 (s, 3H), 3.71 (d, 2H, J=11.1 Hz), 2.8 (bs, 2H), 1.1 (s, 3H)

1. customRemove the solvent
2. custompartition the residue between EtOAc (1 L) and H2O (100 mL)
3. dry with materialRe-extract the aqueous layer with EtOAc, and dry the combined organic fractions over MgSO4
4. filtrationFilter
5. concentrationconcentrate under reduced pressure
6. customCrude mixture can be used without further purification