HCID 69052796, compound → HCID 57832818, compound

Participants

Reaction Steps

Stir a suspension of (2-fluoro-phenyl)-[4-(4-nitro-isoquinoline-1-yloxy)-piperidin-1-yl]-methanone (5.85 g, 14.8 mmol) and palladium on carbon (10%, 2.9 g) in methanol (250 mL) under hydrogen overnight. Remove the catalyst by filtration. Concentrate the filtrate to yield a pale yellow solid (4.7 g, 87% yield, ES+ (m/z) 366.3 [M+H]).

Provenance & Evidence