Trifluoroacetic acid → HCID 57832821, compound

Participants

Reaction Conditions

Reaction Steps

To a cold solution of 4-{4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-ureido]-isoquinolin-1-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (820 mg, 1.37 mmol) in dichloromethane (50 mL), add trifluoroacetic acid (15 mL). Stir the reaction mixture at 22° C. for 1.5 hours. After removal of solvent, treat the residue with 1N sodium hydroxide saturated with NaCl (50 mL) and extract five times with dichloromethane (50 mL each). Dry the combined organic phases over sodium sulfate. Filter the mixture and subject residue to silica gel chromatography eluting with dichloromethane and methanol to provide a white solid (515 mg, 75% yield, LCMS ES+ (m/z) 499.5 [M+H]).

Provenance & Evidence