Methanesulfonic Acid → 1-{1-[1-(2,6-Difluoro-benzoyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea mesylate

Participants

Reaction Steps

Dissolve 0.13 g (0.19 mmol) of 1-{1-[1-(2,6-Difluoro-benzoyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea in dichloromethane (2 mL) and add 0.19 mL of a solution of methanesulfonic acid 1 N in dichloromethane. Evaporation of solvent under reduced pressure gives 0.09 g of the title compound as a white solid. ES+ (m/z) 675 (M+H).

Provenance & Evidence