Methanesulfonic Acid → 1-[5-(1-Fluoromethyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-urea mesylate

Participants

Reaction Steps

Add methanesulfonic acid 1 M (30.17 μmoles; 30.17 μL) to a solution of 1-[5-(1-fluoromethyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-urea (18.00 mg, 30.17 μmoles) in 0.5 mL of Dichloromethane. Stir the mixture at room temperature for 1 hour. Evaporate solvent under nitrogen to afford the title compound as a solid (20 mg, 96% yield). ES+ (m/z): 597.4 [M+1]

Provenance & Evidence