Potassium Carbonate → HCID 66702017, compound

Participants

Reaction Steps

Methanesulfonyl chloride (85 μl) was added to a solution of the subtitle product of step ii) (0.20 g) and N,N-diiosopropylethylamine (0.26 ml) in DCM (10 ml) at 0° C. The ice-bath was removed and stirring maintained for 2 h. The reaction solution was extracted with H2O (2×20 ml) and the organics dried (MgSO4) and concentrated to yield a brown oil. The residue was diluted in methanol (110 ml) and treated with potassium carbonate (0.15 g) for 2 h at room temperature. The volatiles were removed in vacuo and the residue partitioned between EtOAc (20 ml) and H2O (20 ml). The aqueous was further extracted with EtOAc (2×20 ml), the organics combined, dried (MgSO4) and concentrated to yield the subtitle compound as a crude white solid. This material was used directly in the next step. Yield: 0.23 g.

Provenance & Evidence