HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfamide → 1-(Aminosulfonyl)-N,N-dimethyl-D-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfamide | HCID 82267 | — |
| Reactant | (2R)-N,N-dimethylpyrrolidine-2-carboxamide | HCID 7021808 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Aminosulfonyl)-N,N-dimethyl-D-prolinamide | HCID 66702051 | — |
Reaction Steps
To a solution of the subtitle compound of step ii) (2.20 g) in dioxane (25 ml) was added sulfamide (7.20 g) and the mixture heated at reflux for 45 h. The reaction mixture was cooled and adsorbed on to silica gel and then purified by column chromatography (5% methanol/EtOAc) to afford the subtitle compound as an oil. Yield: 1.6 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582644B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-13a8a446f25c4281bc402112d714c1d6 |
| Source note | uspto-grants-2009_09 |