m,alpha-Dichlorotoluene → 4-Amino-2-(3-chlorophenylmethylthio)-6-hydroxypyrimidine

HRID 729657Notes

Reaction equation

HRID 729657 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]Cl>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:15][C:14]2[CH:17]=[CH:18][CH:19]=[C:12]([Cl:11])[CH:13]=2)[NH:6][C:7](=[O:9])[CH:8]=1

Participants

3

Reactant 2

HCID 12103m,alpha-DichlorotolueneHCID 178507962HCID 178507962, compound

Product 1

HCID 1354277124-Amino-2-(3-chlorophenylmethylthio)-6-hydroxypyrimidine

Procedure

The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (10.00 g) with 3-chlorobenzyl chloride (9.98 g) to afford the subtitle compound as a white solid. Yield: 15.00 g.

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-a5410236bd7a4c4188df74519dd31da8
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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