HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-(Dimethylamino)ethanesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Sodium 2-(dimethylamino)ethanesulfonate | HCID 23516383 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Dimethylamino)ethanesulfonyl chloride | HCID 14219657 | — |
Reaction Steps
Phosgene (12 ml, 1M in toluene) was added to a solution of the subtitle product of step i) in DCM (20 ml) and DMF (2.5 ml) and stirred for 3 h before concentrating in vacuo to afford the subtitle compound as an oil that was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582644B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-836c4e875244436d90b9a01b9ab08814 |
| Source note | uspto-grants-2009_09 |