(R)-(-)-2-Amino-1-propanol → HCID 66702006, compound

HRID 729669Notes

Reaction equation

HRID 729669 reaction equation
[CH2:1]([S:8][C:9]1[N:14]=[C:13]([N:15]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[S:16]([N:19]2[CH2:22][CH2:21][CH2:20]2)(=[O:18])=[O:17])[CH:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:32][C@@H:33]([CH2:35][OH:36])[CH3:34]>>[CH2:1]([S:8][C:9]1[N:14]=[C:13]([N:15]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[S:16]([N:19]2[CH2:22][CH2:21][CH2:20]2)(=[O:18])=[O:17])[CH:12]=[C:11]([NH:32][C@H:33]([CH3:34])[CH2:35][OH:36])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 86602820HCID 86602820, compound

Product 1

HCID 66702006HCID 66702006, compound

Procedure

The subtitle compound was prepared as a yellow oil by the method of Example 32 step ii) by reacting the subtitle product of step ii) (12.2 g) with (R)-alaninol (18 ml). Yield: 11.3 g.

Sources & evidence

ORD record
ord-02a6475247394c49ac2a3a985c11a926
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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