Sodium hydrosulfide → HCID 66701883, compound

HRID 729674Notes

Reaction equation

HRID 729674 reaction equation
C([S:8]([C:11]1[N:16]=[C:15]([N:17]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[S:18]([CH3:21])(=[O:20])=[O:19])[CH:14]=[C:13]([NH:30][C@H:31]([CH3:34])[CH2:32][OH:33])[N:12]=1)(=O)=O)C1C=CC=CC=1.O.[SH-].[Na+:37].[SH-].[Na+]>CS(C)=O>[OH:33][CH2:32][C@H:31]([NH:30][C:13]1[CH:14]=[C:15]([N:17]([S:18]([CH3:21])(=[O:19])=[O:20])[CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:28])([CH3:27])[CH3:29])[N:16]=[C:11]([S-:8])[N:12]=1)[CH3:34].[Na+:37]

Participants

5

Reactant 3

HCID 28015Sodium hydrosulfideHCID 16211346Sodium hydrosulfide hydrateHCID 66702087HCID 66702087, compound

Product 1

HCID 66701883HCID 66701883, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of the product of step iii) (3.97 g) in DMSO (30 ml) was added sodium hydrosulphide hydrate (0.84 g). Stirring was continued for a further 2 h and additional aliquots of 0.42 g of sodium hydrosulphide were added until complete disappearance of starting material as assessed by reverse phase HPLC-MS. The subtitle compound was also kept as a stock solution for further reaction with alkyl halides described in examples 43-53 and 137.

Sources & evidence

ORD record
ord-2fdba8f8c1cf429d8bb405b71434d5c8
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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