Potassium Hydroxide → HCID 178490577, compound

HRID 729685Notes

Reaction equation

HRID 729685 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[F:11].[SH:12][C:13]1[N:18]=[C:17]([OH:19])[CH:16]=[C:15]([OH:20])[N:14]=1.[OH-].[K+]>>[F:11][C:4]1[C:5]([O:9][CH3:10])=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][S:12][C:13]1[N:18]=[C:17]([OH:19])[CH:16]=[C:15]([OH:20])[N:14]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 269861001-(Bromomethyl)-2-fluoro-3-methoxybenzeneHCID 178516656HCID 178516656, compound

Product 1

HCID 178490577HCID 178490577, compound

Procedure

The subtitle compound was prepared as a white solid by the method of Example 39 step i) using 1-(bromomethyl)-2-fluoro-3-methoxybenzene (4.5 g), 2-mercaptopyrimidine-4,6-diol (2.96 g) and potassium hydroxide (1.15 g). Yield: 5.0 g.

Sources & evidence

ORD record
ord-c271b35a3e314c10af57dbb78d6cfea0
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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