Lithium Hydroxide → HCID 66701982, compound

Participants

Reaction Steps

Lithium hydroxide (33 mg) was added to a solution of the subtitle product of step i) (0.23 g) in THF/H2O (1 ml/1 ml) and stirring maintained for 1 h. The THF was removed in vacuo and the residue neutralised with AcOH before extracting with EtOAc. The organics were then washed with H2O, dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC (gradient 95% to 20% 0.02M ammonium hydroxide/acetonitrile) to yield the title compound as an off-white solid. Yield: 0.14 g.

Provenance & Evidence