反应详情

温度

20 °C

SOCl2 (8.2 mL, 112.0 mmol) was added to a stirred suspension of (4-methanesulfonylphenyl)acetic acid (20.00 g, 93.3 mmol) in EtOH (80 mL) at −10° C. The mixture was allowed to warm up to 20° C. over 16 h, then the solvents were removed under reduced pressure. The remainder was dissolved in EtOAc, then the resulting solution was washed with H2O until the pH of the aqueous phase was neutral. The EtOAc solution was washed further with saturated aqueous Na2CO3, before being dried (MgSO4). Filtration and solvent evaporation furnished the title compound: m/z (ES+)=284.1 [M+MeCN+H]+.

1. customthe solvents were removed under reduced pressure
2. dissolutionThe remainder was dissolved in EtOAc
3. washthe resulting solution was washed with H2O until the pH of the aqueous phase
4. washThe EtOAc solution was washed further with saturated aqueous Na2CO3
5. dry with materialbefore being dried (MgSO4)
6. filtrationFiltration and solvent evaporation