反应详情

温度

140 °C

A 1-L 3-neck flask equipped with an overhead stirrer, a condenser, and a thermocouple was charged with (8-hydroxymethyl-naphthalen-1-yl)-methanol (33.0 g, 0.175 mol), concentrated phosphoric acid (225 mL), and water (5 mL). The reaction mixture was stirred at 140° C. for 3 h, cooled to room temperature, diluted with CH2Cl2 (800 mL) and transferred to a 2-L separatory funnel. After washing the organic layer with water and saturated NaHCO3 it was dried over MgSO4 and evaporated to yield 1H,3H-Benzo[de]isochromene as a solid.

1. customA 1-L 3-neck flask equipped with an overhead stirrer, a condenser
2. temperaturecooled to room temperature
3. customtransferred to a 2-L separatory funnel
4. washAfter washing the organic layer with water and saturated NaHCO3 it
5. dry with materialwas dried over MgSO4
6. customevaporated