反应详情

6.51 g (0.0300 mol) of 4-bromoveratrole is dissolved in 50 ml of dichloromethane. To this suspension is added 37.6 g (0.150 mol) of boron tribromide at 0° C. The mixture was stirred for 3 hours at room temperature. Solvents were removed under reduced pressure. The resulting brown oil was dissolved in ethyl acetate and filtered through a pad of silica gel. The filtrate was concentrated to afford 5.45 g of 4-bromo catechol as a light brown oil.

1. customSolvents were removed under reduced pressure
2. dissolutionThe resulting brown oil was dissolved in ethyl acetate
3. filtrationfiltered through a pad of silica gel
4. concentrationThe filtrate was concentrated