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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 729889Generated: October 26, 2026

4-Chloro-2-pyridinecarbonitrile → 4-Amino-3-(trifluoromethyl)phenoxyl pyridine-2-carbonitrile

https://huagongshe.com/reaction/729889

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2-pyridinecarbonitrileHCID 693342—
Reactant2-Amino-5-hydroxybenzotrifluorideHCID 14692834—
Reactant4-(3-Aminophenoxy)pyridine-2-carboxamideHCID 23137229—
Product4-Amino-3-(trifluoromethyl)phenoxyl pyridine-2-carbonitrileHCID 86612632—

Reaction Steps

This material is prepared by a method analogous to that described for preparation of 2C, starting from 4-amino-3-(trifluoromethyl)phenol and 4-chloro-2-cyanopyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582645B2
Source datasetuspto-grants-2009_09
ORD IDord-a38d4f9ee7694621b9181727e1cd2ac1
Source noteuspto-grants-2009_09