Ethyl 4-nitrophenylacetate → 4-(2-Chloro-pyridin-4-ylmethyl)-phenylamine

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 4-nitrophenylacetate	HCID 79517	—
Reactant	2-Chloro-4-nitropyridine	HCID 735152	—
Reactant	4-(2-Trifluoromethyl-pyridin-4-ylmethyl)-phenylamine	HCID 57833520	—
Reactant	4-(2-Trifluoromethyl-pyridinylmethyl)-phenylamine	HCID 68968090	—
Product	4-(2-Chloro-pyridin-4-ylmethyl)-phenylamine	HCID 57833405	—

Reaction Steps

4-(2-Chloro-pyridin-4-ylmethyl)-phenylamine was prepared by a method analogous to that described for 4-(2-trifluoromethyl-pyridinylmethyl)-phenylamine (Intermediate 2P), starting from ethyl(4-nitrophenyl)acetate and 2-chloro-4-nitro-pyridine. 1H NMR (CHCl3-d) δ 8.23 (dd, J=5.1, 0.5 Hz, 1H), 7.11 (m, 1H), 7.01 (m, 1H), 6.95 (m, 2H), 6.65 (m, 2H), 3.83 (s, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07582645B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-8bd4b8a20aa547c9901278ef3ce49d88
Source note	uspto-grants-2009_09