HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → Sorafenib Impurity 43
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Methyl 4-chloropyridine-2-carboxylate--hydrogen chloride (1/1) | HCID 16655470 | — |
| Reactant | 4-(3-Aminophenoxy)pyridine-2-carboxamide | HCID 23137229 | — |
| Product | Sorafenib Impurity 43 | HCID 57833322 | — |
Reaction Steps
Methyl 4-(4-aminophenoxy)pyridine-2-carboxylate was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from the product of step 1 and 4-aminophenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582645B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-230623e40d3f4697aaa8ba66f84eb241 |
| Source note | uspto-grants-2009_09 |