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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 729932Generated: October 25, 2026

4-(Trifluoromethyl)benzoic acid → Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

https://huagongshe.com/reaction/729932

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzoic acidHCID 9966—
Reactant2,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 16249—
ReactantEthyl 3-oxo-3-(thiophen-2-yl)propanoateHCID 255159—
Reactant4-(Thiophen-2-yl)pyrimidin-2-amineHCID 2764407—
ProductEthyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoateHCID 2760281—

Reaction Steps

This material is prepared by a method analogous to that described for preparation of ethyl 3-oxo-3-(2-thienyl)propanoate in preparation of 1D, starting from 2,2-dimethyl-1,3-dioxane-4,6-dione and 4-(trifluoromethyl)benzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582646B2
Source datasetuspto-grants-2009_09
ORD IDord-96c3c9900e7f4930b97e02dae2d407da
Source noteuspto-grants-2009_09