4-Chloro-2-pyridinecarbonitrile → HCID 57833446, compound

HRID 729939Notes

Reaction equation

HRID 729939 reaction equation
NC1C=C(C=CC=1)O[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12](N)=O)[CH:7]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([F:26])[CH:20]=1.ClC1C=CN=C(C#N)C=1>>[F:26][C:21]1[CH:20]=[C:19]([NH2:18])[CH:24]=[CH:23][C:22]=1[O:25][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH3:12])[CH:7]=1

Participants

4

Reactant 3

HCID 6933424-Chloro-2-pyridinecarbonitrileHCID 2735918Phenol, 4-amino-2-fluoro-HCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 57833446HCID 57833446, compound

Procedure

{3-Fluoro-4-[(2-methylpyridin-4-yl)oxy]phenyl}-amine (2J) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-amino-2-fluorophenol and 4-chloro-2-cyanopyridine, MS ES: 219 (M+H)+, calcd 219, RT=1.07 min.

Sources & evidence

ORD record
ord-fc788938ada047f6a5a122992b986e32
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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