Water → HCID 178448862, compound

Participants

Reaction Steps

Add sodium dithionite (2.58 g, 14.82 mmol) followed by 32% NH4OH (9 mL) to a solution of {6-[2-(2,6-dichlorophenyl)-5-phenyl-1H-imidazol-4-yl]-3-nitropyridin-2-yl}isobutylamine (1.43 g, 2.96 mmol) in 50 mL of 1:1 THF:water mixture. Stir the mixture at RT for 2 h. Dilute with EtOAc. Wash the organic layer with saturated aqueous NaCl and dry the organic phase over Na2SO4. Concentrate to yield the title compound (1.32 g, 98%).

Provenance & Evidence