反应详情

Add N-bromosuccinimide (7.85 g, 44 mmol) to a solution of 1-benzyl-2-methyl-1H-imidazole (8.0 g, 46 mmol) in chloroform (200 mL) and stir for 6 h. Wash with saturated aqueous sodium hydrogen carbonate and saturated aqueous NaCl, dry over MgSO4, and filter through a pad of silica gel. Concentrate filtrate and suspend the residue in diethyl ether (600 mL), heat to reflux, and filter hot. Concentrate ether filtrate to give the title compound as a tan solid (9.3 g).

1. washWash with saturated aqueous sodium hydrogen carbonate and saturated aqueous NaCl
2. dry with materialdry over MgSO4
3. filtrationfilter through a pad of silica gel
4. temperatureheat
5. temperatureto reflux
6. filtrationfilter hot