HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(4-fluorophenyl)ethan-1-one → 4-(4-Fluorophenyl)-2-methylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Reactant | Thioacetamide | HCID 2723949 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(4-Fluorophenyl)-2-methylthiazole | HCID 731894 | 73.1% |
Reaction Steps
Reflux a solution of 2-bromo-4′-fluoroacetophenone (10 g, 46 mmol) and thioacetamide (6.9 g, 92 mmol) in 1,4-dioxane (60 mL) for 3 h. Filter the precipitate and wash with EtOAc to give the title compound (6.5 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582652B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-70c3659092a04efdb8c2ce74b23b9762 |
| Source note | uspto-grants-2009_09 |