Acetic Acid → HCID 68868291, compound

Participants

Reaction Steps

Heat N′-{5-[2-(2,6-difluorophenyl)-3-methyl-5-phenyl-3H-imidazol-4-yl]-3-isobutyl-3H-imidazo[4,5-b]pyridin-2-yl}-N,N-dimethylformamidine (0.02 g, 0.04 mol) in 1:1 glacial acetic acid:concentrated HCl (0.6 mL) at 100° C. for 30 min. Cool to RT. Add CH2Cl2 and water, neutralize with 5N NaOH to about pH=7 with rapid stirring. Extract the aqueous phase 3× with CH2Cl2, combine organic layers, wash with saturated aqueous NaCl and dry over Na2SO4. Filter and concentrate to give the title compound (0.02 g).

Provenance & Evidence