Methanesulfonic Acid → HCID 178446127, compound

Participants

Reaction Steps

Mix 5-[2-(2,6-dichloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine (11.20 g, 21.99 mmol) in methanol (150 mL), and then add a solution of methanesulfonic acid (2.11 g, 21.96 mmol) in methanol (10 mL) dropwise. Stir at room temperature for 20 minutes and then concentrate under reduced pressure. Add ethyl acetate (150 mL), filter resulting slurry, and wash filter cake with diethyl ether (200 mL). Dry the resulting solid in a drying oven at 80° C. under house vacuum for 2 h to give 12.765 g (95% yield) of the title compound as a light-purple solid.

Provenance & Evidence