Methanesulfonic Acid → HCID 178446129, compound

Participants

Reaction Steps

Mix 3-(2,2-dimethyl-propyl)-5-[5-(4-fluoro-phenyl)-2-(2-fluoro-6-trifluoromethyl-phenyl) -1H-imidazol-4-yl]-3H-imidazo[4,5-b]pyridin-2-ylamine (11.56 g, 21.95 mmol) in methanol (150 mL), and then add a solution of methanesulfonic acid (2.11 g, 21.96 mmol) in MeOH (10 mL) dropwise. Allow the resulting reaction mixture to stir at room temperature for 20 minutes, then concentrate under reduced pressure. Slurry the residue in diethyl ether, filter, and wash with fresh diethyl ether. Dry the resulting solid in a drying oven at room temperature under house vacuum for 48 h to give 12.015 g (87.9% yield) of the title compound as a light-purple solid.

Provenance & Evidence