Dimethyl Sulfate → 2-Hydroxy-5-mercaptobenzoic acid

HRID 730034Notes

Reaction equation

Cl[S:2]([C:5]1[CH:6]=[CH:7][C:8]([OH:15])=[C:9]([CH:14]=1)[C:10]([O:12]C)=[O:11])(=O)=O.S(OC)(OC)(=O)=O>>[OH:15][C:8]1[CH:7]=[CH:6][C:5]([SH:2])=[CH:14][C:9]=1[C:10]([OH:12])=[O:11]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 12581955Methyl 5-(chlorosulfonyl)-2-hydroxybenzoate

Product 1

HCID 214368502-Hydroxy-5-mercaptobenzoic acid

Procedure

6a was prepared from 5a (0.50 g; 2.0 mmol) using the method described in the synthesis of 7c, without alkylation with dimethyl sulfate

Sources & evidence

ORD record: ord-86fa6efbc4ea4f1ead51acb81dc59196
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582660B2

Reaction notes

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