2-Fluoro-4-methylpyridine → 1-(4-Fluorophenyl)-2-(2-fluoropyridin-4-yl)ethanone

HRID 730042Notes

Reaction equation

HRID 730042 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.ClC1C=C(C[C:17]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)=[O:18])C=CN=1>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:17](=[O:18])[CH2:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([F:1])[CH:7]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27374032-Fluoro-4-methylpyridineHCID 108578732-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Product 1

HCID 110317691-(4-Fluorophenyl)-2-(2-fluoropyridin-4-yl)ethanone

Procedure

21b was prepared from 2-fluoro-4-methylpyridine (13.9 g; 125 mmol) using the method described in the synthesis of 21a.

Sources & evidence

ORD record
ord-013214f90d3a41028d264f097d026767
Source dataset
uspto-grants-2009_09
Patent number
US07582660B2

Reaction notes

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