Cyclohexylamine → HCID 24906065, compound

Participants

Reaction Steps

2-Fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-1 H-imidazol-4-yl]pyridine (1.2 g, 4 mmol), which had been weighed out into a 25 ml one-necked flask which had been flushed with argon beforehand, was suspended in cyclohexylamine (3.97 g, 0.04 mol), covered with argon and then heated with reflux of the amine, in an oil bath at a temperature of 160° C., for 48 h. The brown suspension is allowed to cool to RT. 30 ml of Na citrate solution (10% strength citric acid solution pH 5 with conc. NaOH) are then added, and the mixture is stirred for 10 min. and extracted twice with 30 ml of ethyl acetate.

Provenance & Evidence