Potassium Carbonate → HCID 15986280, compound

Participants

Reaction Steps

Potassium carbonate (7.21 g, 52 mmol) was added to a solution of Compound 4a (7.27 g, 18 mmol) in methanol (60 mL), and the reaction was stirred overnight. The reaction was filtered and then ion exchange resin was added (100 g, AG 50W-X210) and the reaction stirred 1 h. The resin was collected by filtration and washed sequentially with water (50 mL) and then methanol (50 mL). The resin was then treated with ammonia in methanol (2M, 500 mL) for 1 h before being collected by filtration again. The filtrate was concentrated under reduced pressure to afford Compound 2 (2.1 g). Procedure 6

Provenance & Evidence