Sodium Hydroxide → HCID 15986633, compound

Participants

Reaction Steps

A solution of 1-{3-[4-(benzhydrylidene-amino)-xanthen-9-ylidene]-8-aza-bicyclo[3.2.1]oct-8-yl}-2,2,2-trifluoroethanone in methanol (0.1 to 1 M solution) may be treated with sodium acetate (2 to 4 equiv) and hydroxylamine hydrochloride (1 to 3 equiv) and stirred at rt for 1 to 4 days. Sodium hydroxide may be added to make the solution basic, and the solution may be stirred at rt for 1 to 5 hr. Methylene chloride and water may be added, and the organic layer may be separated. After drying over a suitable drying agent such as potassium carbonate, filtration, and evaporation, the residue may be purified via reverse phase column chromatography to yield Compound 2c.

Provenance & Evidence