Potassium Sodium Tartrate → HCID 57833588, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 9-[8-(2,2,2-trifluoroacetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-4-carboxylic acid methyl ester in methylene chloride (0.001 to 1 M solution) at −78° C. may be treated with diisobutyl aluminum hydride (1M in cyclohexane; 2 to 10 equiv), and the mixture may be allowed to slowly warm up to 0° C. After stirring at that temperature for a period of 1 to 5 hr, an aqueous solution of Rochelle's salt may be added. The mixture may be extracted with an appropriate organic solvent such as ethyl acetate, and the organic layer may be dried over a suitable drying agent such as potassium carbonate. After filtration and evaporation, the residue may be purified via reverse phase column chromatography to yield Compound 2e.

Provenance & Evidence