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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 730109Generated: October 29, 2026

4-t-Butylbenzenesulfonyl chloride → N-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-tert-butyl-benzenesulfonamide

https://huagongshe.com/reaction/730109

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-t-Butylbenzenesulfonyl chlorideHCID 139882—
Reactant(2-Amino-5-bromophenyl)(pyridin-4-yl)methanoneHCID 13549724—
ProductN-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-tert-butyl-benzenesulfonamideHCID 10412561—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 138 mg of (2-Amino-5-bromo-phenyl)-pyridin-4-yl-methanone and 116 mg of 4-tert-butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.27 (3, 9H), 7.41 (m, 3H), 7.50 (dd, 2H, J=4.8 Hz, 1.6 Hz), 7.67-72 (m, 4H), 8.85 (d, 2H, J=6 Hz), 10.19 (s, 1H). MS: m/z 473.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582661B2
Source datasetuspto-grants-2009_09
ORD IDord-682a56d19f2e4669bb6b7d3eb5bca9ff
Source noteuspto-grants-2009_09