Pyridine → HCID 131726210, compound

Participants

Reaction Steps

0.236 cm3 of pyridine and 26.5 mg of 3-methoxyphenylsulfonyl chloride are added to a solution of 54.1 mg of 3-amino-5-phenyl-6-chloro-1-[(2-trimethylsilylethoxy)methyl]indazole in 2 ml of methylene chloride. The reaction medium is stirred at ambient temperature for 24 hours and then evaporated. The purification of the crude product by chromatography on silica (eluent: methylenechloride/acetone (98/2, v/v)) makes it possible to obtain 70 mg of 1N-[6-chloro-5-phenyl-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-indazol-3-yl]-3-methoxybenzenesulfonamide (colorless foam).

Provenance & Evidence