Sulfur Dioxide → HCID 23690620, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzofuran (10 mmol) in dry THF (15 mL) at −40° C., n-BuLi (2.5 M in hexanes; 4.4 mL; 11 mmol) was added dropwise. The reaction mixture was stirred at −40° C. for 30-40 min. Sulfur dioxide gas was passed into the reaction mixture, keeping the tip of the needle just above the reaction mixture, for about 5-10 min. A white precipitate was formed. The reaction mixture was then brought to RT and the stirring was continued for 1 h, then the mixture was diluted with hexane (20 mL) to give benzofuran-2-sulfinic acid lithium salt as a white precipitate. The solid was filtered and dried in vacuo to afford the salt.

Provenance & Evidence