HCID 10702137, compound → HCID 10172435, compound

HRID 730282Notes

Reaction equation

HRID 730282 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([CH3:11])[C:8](/[CH:12]=[CH:13]/[C:14]([OH:16])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]([CH2:27][OH:28])=[CH:21]2>>[C:1]([C:5]1[N:10]=[C:9]([CH3:11])[C:8](/[CH:12]=[CH:13]/[C:14]([NH:17][C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[NH:23][C:22]([CH2:27][OH:28])=[CH:21]3)=[O:16])=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 10702137HCID 10702137, compoundHCID 57808155(2E)-3-[6-(1,1-Dimethylethyl)-2-methyl-3-pyridinyl]-2-propenoic acid

Product 1

HCID 10172435HCID 10172435, compound

Procedure

Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (110 mg, 0.50 mmol) and (5-aminoindol-2-yl)methan-1-ol, Example 74(b), (81, 0.50 mmol) provided, after purification by silica gel chromatography (25:75 hexane:EtOAc), the title compound as a pale yellow solid. MP 213° C. MS (ESI, pos. ion) m/z: 364 (M+1).

Workup

  1. customprovided
  2. customafter purification by silica gel chromatography (25:75 hexane:EtOAc)

Sources & evidence

ORD record
ord-3ed9d06441bc45d8ae5e5de1e3561fdd
Source dataset
uspto-grants-2009_09
Patent number
US07582657B2

Reaction notes

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