6-Aminobenzothiazole → HCID 10237139, compound

HRID 730286Notes

Reaction equation

HRID 730286 reaction equation
[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[NH2:17][C:18]1[CH:26]=[CH:25][C:21]2[N:22]=[CH:23][S:24][C:20]=2[CH:19]=1>>[S:24]1[C:20]2[CH:19]=[C:18]([NH:17][C:10](=[O:12])/[CH:9]=[CH:8]/[C:7]3[C:2]([CH3:1])=[N:3][C:4]([C:13]([F:16])([F:15])[F:14])=[CH:5][CH:6]=3)[CH:26]=[CH:25][C:21]=2[N:22]=[CH:23]1

Participants

3

Reactant 2

HCID 682886-AminobenzothiazoleHCID 57808084HCID 57808084, compound

Product 1

HCID 10237139HCID 10237139, compound

Procedure

Analogous to the procedure used to prepare Example 1, (2E)-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 82(b), (120 mg, 0.50 mmol) and 6-aminobenzothiazole (75 mg, 0.50 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a white solid. MP 196° C. MS (ESI, pos. ion) m/z: 364 (M+1).

Workup

  1. customprovided
  2. customafter purification by silica gel chromatography (55:45 hexane:EtOAc)

Sources & evidence

ORD record
ord-7c3d98e51de14e42a017250812b34b5c
Source dataset
uspto-grants-2009_09
Patent number
US07582657B2

Reaction notes

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