HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Aminobenzothiazole → (2E)-N-Benzothiazol-6-yl-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Aminobenzothiazole | HCID 68288 | — |
| Reactant | 2-Bromo-4-(trifluoromethyl)cinnamic acid | HCID 57808143 | — |
| Product | (2E)-N-Benzothiazol-6-yl-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enamide | HCID 57808138 | — |
Reaction Steps
Analogous to the procedure used to prepare Example 1, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 97(e), (140 mg, 0.47 mmol) and 6-aminobenzothiazole (86 mg, 0.57 mmol, Lancaster) provided, after purification by silica gel chromatography (gradient: 0-30% EtOAc in hexane), the title product as an off-white solid. MP 214-215° C. MS (ESI, pos. ion) m/z: 427 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582657B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-013eb4c6bce440919d1ab09331edc992 |
| Source note | uspto-grants-2009_09 |