N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → HCID 57594329, compound

HRID 730346Notes

Reaction equation

HRID 730346 reaction equation
[NH2:1][CH2:2][C@@H:3]([NH:21][C:22](=[O:34])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([CH3:32])[CH3:31])=[C:25]([Cl:33])[CH:24]=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1.CC(OC([NH:42][C:43]([CH3:48])([C:45](O)=[O:46])[CH3:44])=O)(C)C>>[Cl:33][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][C:26]=1[O:29][CH:30]([CH3:32])[CH3:31])[C:22]([NH:21][C@@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1)[CH2:2][NH:1][C:45](=[O:46])[C:43]([CH3:48])([CH3:44])[NH2:42])=[O:34]

Participants

3

Reactant 2

HCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 57594616HCID 57594616, compound

Product 1

HCID 57594329HCID 57594329, compound

Procedure

Following the procedure described above with N-((1S)-2-amino-1-{[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]methyl}ethyl)-3-chloro-4-[(1-methylethyl)oxy]benzamide and N-{[(1,1-dimethylethyl)oxy]carbonyl}-2-methylalanine provided the title product as a white solid. ESMS [M+H]+: 563.2.

Sources & evidence

ORD record
ord-014e4540d2d646e9aeafd0472f8be95a
Source dataset
uspto-grants-2009_09
Patent number
US07582668B2

Reaction notes

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