Potassium Hydroxide → [5-Cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid

HRID 730392Notes

Reaction equation

C([O:3][C:4](=[O:32])[CH2:5][N:6]1[C:12](=[O:13])[N:11]([CH2:14][C:15]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:16])[C:10]2[CH:22]=[CH:23][CH:24]=[CH:25][C:9]=2[C:8]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[N:7]1)C.[OH-].[Na+].[OH-].[K+]>>[CH:26]1([C:8]2[C:9]3[CH:25]=[CH:24][CH:23]=[CH:22][C:10]=3[N:11]([CH2:14][C:15]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)=[O:16])[C:12](=[O:13])[N:6]([CH2:5][C:4]([OH:32])=[O:3])[N:7]=2)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 14798Sodium Hydroxide

HCID 16225985[5-Cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid ethyl ester

Product 1

HCID 16733315[5-Cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid

Procedure

The [5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid ethyl ester is reacted with an aqueous base such as NaOH, KOH, and the like, according to known methods, to yield [5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl )-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid, which is preferably isolated, according to known methods.

Sources & evidence

ORD record: ord-ac9795bb22ed45e2825edde4ede8bd54
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582753B2

Reaction notes

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