Hydrochloric Acid → HCID 69058882, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl (E)-3-[3-cyano-4,6-dimethyl-1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-propenoate (1.2 g, 3 mmol) in tetrahydrofuran (6 ml)-toluene (6 ml) was heated to 50° C. To the resultant solution was added a 2 N aqueous sodium hydroxide solution (4 ml, 8 mmol) and the mixture was stirred at 50° C. for 20 minutes. Then, water (100 ml) was added to the reaction mixture, which was adjusted to pH 3 to 4 with 12 N hydrochloric acid, and then the product was extracted using ethyl acetate-tetrahydrofuran (3:1, v/v). The organic extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was removed under vacuum. Hexane was added to the residue on a solid material and the residue was finely crushed using a spatula. The solid was collected by filtration using Kiriyama Roht and was washed with hexane to give the title compound (yield (amount) 1.0 g, yield (rate) 92%).

Provenance & Evidence