4-(Methylamino)tetrahydro-2H-pyran → HCID 69060995, compound

HRID 730412Notes

Reaction equation

[C:1]([C:3]1[C:11]2[C:6](=[N:7][C:8]([CH3:12])=[CH:9][CH:10]=2)[N:5]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14]2)[C:4]=1/[CH:22]=[CH:23]/[C:24]([NH:26][CH:27]1[CH2:32][CH2:31][O:30][C:29](C)(C)[CH2:28]1)=[O:25])#[N:2].[C:35](C1C2C(=NC(C)=CC=2)N(C2C3C(=CC=CC=3)CC2)C=1/C=C/C(O)=O)#N.CNC1CCOCC1>>[C:1]([C:3]1[C:11]2[C:6](=[N:7][C:8]([CH3:12])=[CH:9][CH:10]=2)[N:5]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14]2)[C:4]=1/[CH:22]=[CH:23]/[C:24]([N:26]([CH3:35])[CH:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1)=[O:25])#[N:2]

Participants

Reactant 3

HCID 69919504-(Methylamino)tetrahydro-2H-pyran

HCID 69058562HCID 69058562, compound

HCID 69063358HCID 69063358, compound

Product 1

HCID 69060995HCID 69060995, compound

Procedure

In the same manner described in (4) of Example 2, (E)-3-[3-cyano-1-(2,3-dihydro-iH-inden-1-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-methyl-N-tetrahydro-2H-pyran-4-yl-2-propenamide was synthesized from (E)-3-[3-cyano-1-(2,3-dihydro-1H-inden-1-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-propenoic acid and N-methyltetrahydro-2H-pyran-4-ylamine.

Sources & evidence

ORD record: ord-6f8d4406066643a4a4d314b71e019ed6
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582651B2

Reaction notes

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