Hydrochloric Acid → HCID 69058556, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (2E)-3-[3-cyano-1-(indan-1-yl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]acrylate (5.54 g) was dissolved in ethanol-tetrahydrofuran (1 : 1, v/v) (60 ml) and a 2 N aqueous sodium hydroxide solution (14.4 ml) was added thereto at 50° C. After agitating the mixture at 50° C. for 40 minutes, the reaction solution was poured into water (300 ml), and concentrated hydrochloric acid was added thereto to adjust the pH to 3 to 4. The resultant mixture was extracted with ethyl acetate-tetrahydrofuran (3:1, v/v). After the organic layer was washed with water and dried (over anhydrous magnesium sulfate), the solvent was distilled off under reduced pressure and the crystal was collected by filtration to give (2E)-3-[3-cyano-1-(indan-1-yl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]acrylic acid (4.55 g, 89%).

Provenance & Evidence