反应详情

温度

-40 °C

Chlorosulfonyl isocyanate (17 mL, 195 mmol) was dissolved in nitroethane (150 mL) and cooled to −40° C. A solution of 4-methoxyaniline (20 g, 162 mmol) in nitroethane (100 mL) was then added dropwise with stirring. After the addition was completed, the reaction was stirred for an additional 5 min and aluminum chloride (25 g, 195 mmol) was added. The mixture was then quickly heated to 110° C. with stirring for 20 min. The crude material was then poured onto ice and the precipitate was collected by vacuum filtration, washed with cold water, and dried in vacuo to afford the desired product, 7-methoxy-1,1-dioxo-1,4-dihydro-2H-1λ6-benzo[1,2,4]thiadiazin-3-one (35 g, 153.5 mmol, 79% yield) as a purple powder. 1H NMR (400 MHz, DMSO-d6): δ 3.6 (br, 1H), 3.78 (s, 3H), 7.2 (m, 3H), 11.05 (s, 1H).

1. additionAfter the addition
2. stirringthe reaction was stirred for an additional 5 min
3. temperatureThe mixture was then quickly heated to 110° C.
4. stirringwith stirring for 20 min
5. filtrationthe precipitate was collected by vacuum filtration
6. washwashed with cold water
7. customdried in vacuo