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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 730577Generated: October 27, 2026

3-Fluorobenzyl bromide → {2-[1-(3-fluoro-benzyl)-1H-indol-4-yloxy]-ethyl}-methyl-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/730577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluorobenzyl bromideHCID 68007—
Reactant[2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl esterHCID 10708626—
ReactantSodium hydroxide ethanolHCID 23692425—
Product{2-[1-(3-fluoro-benzyl)-1H-indol-4-yloxy]-ethyl}-methyl-carbamic acid tert-butyl esterHCID 68813743—

Reaction Steps

[2-(1H-Indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester was treated NaOH/EtOH followed by addition of 3-fluorobenzylbromide as described above in Step 1 of Example 5 to afford {2-[1-(3-fluoro-benzyl)-1H-indol-4-yloxy]-ethyl}-methyl-carbamic acid tert-butyl ester. MS: 299 (M−Boc+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582760B2
Source datasetuspto-grants-2009_09
ORD IDord-6785193c19ef48f990244187075a148c
Source noteuspto-grants-2009_09