1-(1-Benzyl-4-methyl-piperidin-4-yl)-4-methyl-piperazine → 1-Methyl-4-(4-methylpiperidin-4-yl)piperazine

Participants

Reaction Steps

A suspension of 0.99 g (3.27 mmol) 1-(1-benzyl-4-methyl-piperidin-4-yl)-4-methyl-piperazine and 200 mg 10% Pd/C in 25 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 2 h. To complete the reaction a further 200 mg catalyst were added and the reaction mixture was hydrogenated for a further 22 h at 60° C. and 50 psi hydrogen pressure. The catalyst was filtered off and the filtrate evaporated to dryness. The product was reacted further without purification.

Provenance & Evidence